Abstract
In 4 siblings, of whom 2 had symptoms of Wilson's disease, electron microscopy showed that the number and size of lysosomes in the enterocytes were increased compared with controls. Electron-dense aggregates, observed near the lysosomes in the 2 symptomatic patients and 1 other sibling, were shown, by means of a microanalytical method, to contain copper. These findings could suggest a possible role of the small intestine in Wilson's disease.
MeSH terms
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Copper / metabolism*
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Epithelium / metabolism
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Epithelium / ultrastructure
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Hepatolenticular Degeneration / genetics
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Hepatolenticular Degeneration / metabolism
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Hepatolenticular Degeneration / pathology*
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Histocytochemistry
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Humans
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Intestinal Mucosa / metabolism
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Intestinal Mucosa / ultrastructure*
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Intestine, Small / metabolism
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Intestine, Small / ultrastructure*
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Jejunum / metabolism
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Jejunum / ultrastructure
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Lysosomes / ultrastructure*