doi: 10.1126/science.169.3943.392.
Visualization of bacterial genes in action
- PMID: 4915822
- DOI: 10.1126/science.169.3943.392
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Visualization of bacterial genes in action
Science.
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Abstract
The morphology of active structural and putative ribosomal RNA genes was observed by electron microscopy after lysis of fragile Escherichia coli cells. Conclusions drawn are: most of the chromosome is not genetically active at any one instant; translation is completely coupled with transcription; the 16S and 23S ribosomal RNA cistrons occur in tandem, in regions which are widely spaced on the chromosome.
Comment in
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The Ribosome Holds the RNA Polymerase on Track in Bacteria.Trends Biochem Sci. 2017 Sep;42(9):686-689. doi: 10.1016/j.tibs.2017.07.003. Epub 2017 Aug 8. Trends Biochem Sci. 2017. PMID: 28801047
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