Comparative trial of Nutrizym in chronic pancreatic insufficiency

Br Med J. 1970 Oct 3;4(5726):21-4. doi: 10.1136/bmj.4.5726.21.


A cross-over trial of pancreatic replacement therapy was carried out in 12 adults with chronic pancreatic insufficiency. The standard enteric-coated preparation, Pancrex V forte, was compared with Nutrizym, which has an enteric-coated core of pancreatic extract and a shell of bromelains-a mixture of proteolytic enzymes derived from the stem of the pineapple.Nutrizym was significantly more effective than Pancrex V forte in improving fat absorption, and reduced faecal weight. Protein digestion was assessed by measuring the urinary excretion of hydroxyproline after a gelatin meal. Nutrizym produced an earlier and significantly higher peak in hydroxyproline excretion than Pancrex V forte, but the cumulative effect was similar. The value of bromelains was investigated by including a period on the Nutrizym core alone. This was similar to Pancrex V forte in improving fat absorption but had less effect on protein digestion, suggesting that the beneficial effect of Nutrizym compared with Pancrex V forte was due to the added bromelains, and not to differences in enzyme content or enteric coating.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Amylases / therapeutic use*
  • Bromelains / therapeutic use*
  • Clinical Trials as Topic
  • Fats / metabolism
  • Feces
  • Female
  • Gelatin / metabolism
  • Humans
  • Hydroxyproline / urine
  • Lipase / therapeutic use*
  • Male
  • Middle Aged
  • Pancreatic Diseases / drug therapy*
  • Pancreatin / therapeutic use*
  • Trypsin / therapeutic use*


  • Fats
  • Pancreatin
  • Gelatin
  • Bromelains
  • Lipase
  • Amylases
  • Trypsin
  • Hydroxyproline