Bombesin suppresses feeding in rats

Nature. 1979 Nov 8;282(5735):208-10. doi: 10.1038/282208a0.


Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like immunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Bombesin / pharmacology*
  • Cholecystokinin / pharmacology
  • Depression, Chemical
  • Drinking Behavior / drug effects
  • Feeding Behavior / drug effects*
  • Male
  • Peptides / pharmacology*
  • Rats
  • Satiation / drug effects*


  • Peptides
  • Cholecystokinin
  • Bombesin