Effect of Deglycyrrhizinated Liquorice on Gastric Mucosal Damage by Aspirin

Scand J Gastroenterol. 1979;14(5):605-7. doi: 10.3109/00365527909181397.

Abstract

Gastric mucosal damage induced by giving 60 mg aspirin orally to rats was reduced by simultaneous administration of 100-500 mg deglycyrrhizinated liquorice. Human faecal blood loss induced by 975 mg aspirin orally three times a day was less when 350 mg deglycyrrhizinated liquorice was given with each dose of aspirin.

MeSH terms

  • Adult
  • Animals
  • Aspirin* / administration & dosage
  • Drug Evaluation, Preclinical
  • Gastric Mucosa / drug effects*
  • Glycyrrhiza*
  • Humans
  • Male
  • Middle Aged
  • Peptic Ulcer Hemorrhage / chemically induced
  • Peptic Ulcer Hemorrhage / prevention & control
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal*
  • Rats
  • Stomach Ulcer / chemically induced*
  • Stomach Ulcer / prevention & control

Substances

  • Plant Extracts
  • deglycyrrhizinized liquorice
  • Aspirin