Oscillations of granulocytic and megakaryocytic progenitor cell populations in cyclic neutropenia in man

Scand J Haematol. 1979 Jul;23(1):33-6. doi: 10.1111/j.1600-0609.1979.tb02850.x.


The concentration of granulocytic progenitor cells in the bone marrow of 2 patients with cyclic neutropenia was assessed at intervals during the cycle. Syncroneous oscillations were observed for cells forming neutrophilic and megakaryocytic colonies in diffusion chambers in vivo (CFU-D), suggesting a close relationship between the two cell types. However, an almost reverse relationship was observed between CFU-D and cells forming colonies in agar culture in vitro (CFU-C), which cycled out of phase with CFU-D. This supports the concept that CFU-D and CFU-C denote different cell types.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Agranulocytosis / blood*
  • Cells, Cultured
  • Colony-Forming Units Assay
  • Granulocytes / physiology*
  • Hematopoiesis*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Leukocyte Count
  • Megakaryocytes / physiology*
  • Neutropenia / blood*