Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum

Science. 1979 Nov 2;206(4418):577-80. doi: 10.1126/science.493963.


D-Arabinitol was identified as a major metabolite of Candida species in human subjects. Gas-liquid chromatography was used to measure the concentration of D-arabinitol in serum. The study included subjects who were healthy and cancer patients who had proven invasive candidiasis or were colonized with Candida. D-Arabinitol concentrations greater than 1.0 microgram per milliliter were found in serum from patients with invasive infection. This technique may prove valuable in the diagnosis of invasive candidiasis.

MeSH terms

  • Arabinose / analogs & derivatives
  • Arabinose / blood
  • Candidiasis / blood
  • Candidiasis / diagnosis*
  • Chromatography, Gas
  • Humans
  • Mass Spectrometry
  • Sugar Alcohols / blood*


  • Sugar Alcohols
  • Arabinose
  • arabitol