Immunogenicity and specificity of collagen. XII. Demonstration by immunofluorescence and haemagglutination of antibodies with different specificity to human collagen

Immunology. 1971 Oct;21(4):649-57.


A comparative investigation, using haemagglutination, haemagglutination-inhibition and immunofluorescence, was performed for demonstration of antibodies with different types of collagen specificity. In rabbit antisera to acid-soluble human collagen a fraction of species-specific antibodies to human collagen and a fraction of general, non-species-specific collagen antibodies could be demonstrated in good accordance by both techniques. Calf, rabbit, rat and guinea-pig collagen were used as heterologous control preparations.

MeSH terms

  • Adsorption
  • Animals
  • Antibody Specificity*
  • Cattle
  • Collagen*
  • Fluorescent Antibody Technique
  • Guinea Pigs
  • Hemagglutination Inhibition Tests
  • Hemagglutination Tests
  • Humans
  • Immune Sera
  • Rabbits
  • Rats
  • Solubility
  • Species Specificity
  • Spleen / immunology


  • Immune Sera
  • Collagen