The effects of ions on the binding of agonists and antagonists to muscarinic receptors

Br J Pharmacol. 1979 Nov;67(3):371-7. doi: 10.1111/j.1476-5381.1979.tb08690.x.

Abstract

1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.

MeSH terms

  • Animals
  • Brain / metabolism
  • Carbachol / metabolism
  • Choline / analogs & derivatives
  • Choline / metabolism
  • Ions / pharmacology*
  • Parasympatholytics / metabolism*
  • Parasympathomimetics / metabolism*
  • Potassium Chloride / pharmacology
  • Rats
  • Receptors, Cholinergic / metabolism*
  • Receptors, Muscarinic / metabolism*
  • Scopolamine / metabolism
  • Sodium Chloride / pharmacology

Substances

  • Ions
  • Parasympatholytics
  • Parasympathomimetics
  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • Sodium Chloride
  • Potassium Chloride
  • Carbachol
  • Scopolamine
  • Choline