Hemodynamic improvement following a single dose of oral phentolamine. Administration in patients with chronic low output cardiac failure

Chest. 1979 Nov;76(5):571-5. doi: 10.1378/chest.76.5.571.

Abstract

Hemodynamic studies were made in 15 patients with chronic low output cardiac failure before and following a single dose of oral phentolamine (150 mg). After two hours significant (P less than .05) reduction occurred in mean pulmonary, wedge and right atrial pressures and increases in cardiac index and heart rate. In ten patients studied at four hours, wedge pressure remained significantly reduced (-18 percent) and cardiac index significantly increased (+19 percent) from control values. Oral phentolamine results in significant hemodynamic improvement in patients with severe heart failure. Duration of effect for at least four hours after a single dose suggests that intermittent oral therapy may be useful in the management of such patients.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Oral
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Cardiac Output, Low / drug therapy*
  • Heart Failure / drug therapy*
  • Heart Rate / drug effects
  • Humans
  • Male
  • Middle Aged
  • Phentolamine / administration & dosage*

Substances

  • Phentolamine