6 -Hydroxy- 1 -Tetrahydrocannabinol Synthesis and Biological Activity

Science. 1971 Nov 26;174(4012):951-2. doi: 10.1126/science.174.4012.951.

Abstract

6beta-Hydroxy-delta(1)-tetrahydrocannabinol, a metabolite of delta(1)-tetrahydrocannabinol has been synthesized from delta(6)-tetrahydrocannabinol. It shows high tetrahydrocannabinol-type activity in rhesus monkeys. The implications of this funding are discussed.

MeSH terms

  • Animals
  • Cannabis / metabolism*
  • Chromatography
  • Dronabinol / administration & dosage
  • Dronabinol / analysis
  • Dronabinol / metabolism
  • Dronabinol / pharmacology
  • Haplorhini
  • Motor Activity / drug effects

Substances

  • Dronabinol