Abstract
The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine. The supine and erect systolic pressures were significantly higher and the erect pulse rate significantly lower during administration of L-alpha-methyldopahydrazine. The implications of these observations are discussed.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adult
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Aged
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Blood Pressure / drug effects*
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Dihydroxyphenylalanine / blood
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Dihydroxyphenylalanine / pharmacology*
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Dihydroxyphenylalanine / therapeutic use
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Dopamine / pharmacology
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Female
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Humans
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Hydrazines / pharmacology
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Hydrazines / therapeutic use
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Hypotension / chemically induced
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Male
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Methyldopa / pharmacology*
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Methyldopa / therapeutic use
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Middle Aged
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Parkinson Disease / drug therapy
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Pulse / drug effects
Substances
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Hydrazines
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Methyldopa
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Dihydroxyphenylalanine
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Dopamine