Prevention of neurosurgical infection by intraoperative antibiotics

Neurosurgery. 1979 Sep;5(3):339-43.


For the past 5 years at Mount Sinai Hospital, an intraoperative prophylactic antibiotic regime consisting of intramuscular gentamicin or tobramycin, intravenous vancomycin, and streptomycin irrigating solution, with no preoperative or post operative antibiotics, has provided complete protection against operative infections in neurological surgery. There have been 1732 major clean operative cases with no instance of operative infection and no complication due to the antibiotics.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / prevention & control*
  • Gentamicins / therapeutic use
  • Humans
  • Neurosurgery*
  • Premedication*
  • Streptomycin / therapeutic use
  • Surgical Wound Infection / prevention & control*
  • Tobramycin / therapeutic use
  • Vancomycin / therapeutic use


  • Anti-Bacterial Agents
  • Gentamicins
  • Vancomycin
  • Tobramycin
  • Streptomycin