Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds

Science. 1972 Jul 7;177(4043):65-8. doi: 10.1126/science.177.4043.65.

Abstract

The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid. The extent of blocking depended on the compound nitrosated and on the experimental conditions. Urea and ammonium sulfamate were less effective as blocking agents. The possibility of in vivo formation of carcinogenic N-nitroso compounds from drugs could be lessened by the combination of such drugs with the ascorbic acid.

MeSH terms

  • Aniline Compounds
  • Ascorbic Acid*
  • Carcinogens*
  • Chemical Phenomena
  • Chemistry
  • Depression, Chemical
  • Hydrogen-Ion Concentration
  • Kinetics
  • Methylamines
  • Morpholines
  • Nitrites*
  • Nitroso Compounds*
  • Oxytetracycline
  • Piperazines
  • Structure-Activity Relationship
  • Urea

Substances

  • Aniline Compounds
  • Carcinogens
  • Methylamines
  • Morpholines
  • Nitrites
  • Nitroso Compounds
  • Piperazines
  • Urea
  • Ascorbic Acid
  • Oxytetracycline