A metabolic interaction in vivo between cannabidiol and 1 -tetrahydrocannabinol

Br J Pharmacol. 1972 Jun;45(2):375-7. doi: 10.1111/j.1476-5381.1972.tb08092.x.


The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Delta(1)-tetrahydrocannabinol ((3)H-Delta(1)-THC; 1.0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Delta(1)-THC and its centrally active metabolite 7-hydroxy-Delta(1)-THC: the changes produced were respectively 1.4 and 2.0 fold.Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Delta(1)-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.

MeSH terms

  • Animals
  • Biological Assay
  • Brain / metabolism*
  • Cannabis / metabolism*
  • Chromatography
  • Dronabinol / metabolism
  • Male
  • Rats
  • Tritium


  • Tritium
  • Dronabinol