Möbius syndrome. Neuropathologic observations

Acta Neuropathol. 1979 Oct;48(1):11-7. doi: 10.1007/BF00691785.


Neuropathologic findings in an infant with congenital right facial and bilateral lateral rectus palsy (Möbius syndrome) are presented. Multiple microscopic foci of necrosis were found in the lower pontine tegmentum, involving the region of the intramedullary course of 6th and 7th cranial nerves. The significance of pathologic findings in this infant and 14 additional published cases of Möbius syndrome is discussed.

Publication types

  • Case Reports

MeSH terms

  • Abducens Nerve*
  • Abnormalities, Multiple / pathology
  • Autopsy
  • Facial Paralysis / congenital*
  • Facial Paralysis / pathology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Necrosis
  • Ophthalmoplegia / congenital*
  • Ophthalmoplegia / pathology
  • Pons / pathology
  • Syndrome