Uveal malignant melanoma in three generations of the same family

Am J Ophthalmol. 1979 Oct;88(4):723-6. doi: 10.1016/0002-9394(79)90672-x.


Three patients in three successive generations from the same family had choroidal malignant melanoma. The third generation patient had multiple primary malignancies; his siblings also had multiple malignancies. Chromosome studies of the third generation patient revealed no abnormality. To the best of our knowledge, this is the second such pedigree reported.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Eye Neoplasms / genetics*
  • Eye Neoplasms / pathology
  • Female
  • Humans
  • Male
  • Melanoma / genetics*
  • Melanoma / pathology
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / pathology
  • Pedigree
  • Uveal Diseases / genetics*
  • Uveal Diseases / pathology