Continuous muscle fiber activity: a case with unusual clinical features

Arch Neurol. 1979 Aug;36(8):520-1. doi: 10.1001/archneur.1979.00500440090022.


A patient with continuous muscle fiber activity is described. From our search of the literature, we believe this is the oldest patient with a reported case of this disorder, and the symptoms and treatment varied from previously reported cases in these respects: symptoms remained confined to the lower extremities after 18 months had elapsed, there was no response to phenytoin sodium or carbamazepine, and the patient required a full dose of tubocurarine chloride to stop the abnormal myoelectric potentials. A site of dysfunction in the unbranched motor axon is suggested as the locus of generation of the stimulus for the abnormal myoelectric activity.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carbamazepine / therapeutic use
  • Female
  • Humans
  • Motor Activity
  • Muscular Diseases / drug therapy
  • Muscular Diseases / physiopathology*
  • Phenytoin / therapeutic use
  • Tubocurarine / therapeutic use


  • Carbamazepine
  • Phenytoin
  • Tubocurarine