Herpes simplex keratitis treatment with vitamin A

Arch Ophthalmol. 1979 Nov;97(11):2181-3. doi: 10.1001/archopht.1979.01020020499019.


We produced chronic experimental herpetic keratitis by dropping PH-strain herpes simplex virus on scarified rabbit corneas and then injecting the rabbits subconjunctivally with low doses of corticosteroid (namely, triamcinolone acetonide suspension). Vitamin-A-treated rabbits developed milder, more rapidly healing epithelial lesions than untreated rabbits. Whereas most of the untreated rabbits developed moderate or severe stromal disease, most of the vitamin-A-treated rabbits developed only mild stromal disease or none at all.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Keratitis, Dendritic / diagnosis
  • Keratitis, Dendritic / drug therapy*
  • Male
  • Rabbits
  • Vitamin A / therapeutic use*


  • Vitamin A