The occurrence of tolerance to a central depressant effect of nicotine

Br J Pharmacol. 1972 Sep;46(1):151-6. doi: 10.1111/j.1476-5381.1972.tb06857.x.


1. Rats were injected with 0.8 mg nicotine/kg, 0.8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Depression, Chemical
  • Drug Tolerance*
  • Male
  • Motor Activity / drug effects*
  • Nicotine / pharmacology*
  • Rats


  • Nicotine
  • Amphetamine