Fertility in women with Turner's syndrome. Case report and review of literature

Br J Obstet Gynaecol. 1979 Nov;86(11):833-5. doi: 10.1111/j.1471-0528.1979.tb10706.x.

Abstract

A successful pregnancy in a woman with Turner's syndrome with a 45,X/46,XX karyotype is described. The literature contains reports of a total of nine pregnancies in seven women with a 45,X karyotype and 56 pregnancies in 23 women with mosaicism and a 45,X cell line, as well as a 46,XX and/or 47,XXX cell line. Fifteen of the latter 56 pregnancies ended in spontaneous abortion (27 per cent), and four ended in the delivery of a stillborn child; 12 of the 37 liveborn infants (32 per cent) had a physical or mental abnormality, and 8 (22 per cent) had a chromosome abnormality. Three had Down's syndrome, and five had a 45,X cell line. Due to the relatively high (8 per cent) incidence of Down's syndrome among liveborn infants of women with Turner's syndrome, amniocentesis for fetal karyotyping should be advised.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fertility*
  • Fertilization
  • Humans
  • Infant, Newborn
  • Karyotyping
  • Menstruation
  • Pregnancy
  • Pregnancy Complications
  • Turner Syndrome* / genetics