Systemic absorption of topically applied chloramphenicol eyedrops

Br J Ophthalmol. 1979 Oct;63(10):690-1. doi: 10.1136/bjo.63.10.690.


Five children under the age of 9 years had topical chloramphenicol drops administered 2-hourly to each eye for 5 to 7 days. Systemic absorption was not detected by 2 sensitive assays for the drug. The hazards of topical chloramphenicol and reports in the current literature are discussed.

MeSH terms

  • Absorption
  • Child
  • Child, Preschool
  • Chloramphenicol / administration & dosage
  • Chloramphenicol / metabolism*
  • Chloramphenicol / urine
  • Drug Administration Schedule
  • Humans
  • Ophthalmic Solutions


  • Ophthalmic Solutions
  • Chloramphenicol