Abstract
Intravenous administration of [(3)H]lysergic acid diethylamide(LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Autoradiographic methods were used to differentiate free and bound [(3)H]LSD in brain tissue. Free [(3)H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus,and choroid plexus. Bound [(3)H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla,as well as in choroid plexus epithelium.
MeSH terms
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Animals
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Autoradiography
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Binding Sites
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Brain Chemistry*
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Caudate Nucleus / analysis
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Cerebellum / analysis
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Cerebral Cortex / analysis
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Choroid Plexus / analysis
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Freeze Drying
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Hippocampus / analysis
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Histocytochemistry
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Injections, Intravenous
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Lysergic Acid Diethylamide / administration & dosage
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Lysergic Acid Diethylamide / analysis*
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Lysergic Acid Diethylamide / metabolism
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Mesencephalon / analysis
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Olivary Nucleus / analysis
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Pineal Gland / analysis
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Pituitary Gland / analysis
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Purkinje Cells / analysis
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Rats
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Superior Colliculi / analysis
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Tegmentum Mesencephali / analysis
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Time Factors
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Tritium
Substances
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Tritium
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Lysergic Acid Diethylamide