( 3 H)lysergic acid diethylamide: cellular autoradiographic localization in rat brain

Science. 1971 Sep 10;173(4001):1022-4. doi: 10.1126/science.173.4001.1022.

Abstract

Intravenous administration of [(3)H]lysergic acid diethylamide(LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Autoradiographic methods were used to differentiate free and bound [(3)H]LSD in brain tissue. Free [(3)H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus,and choroid plexus. Bound [(3)H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla,as well as in choroid plexus epithelium.

MeSH terms

  • Animals
  • Autoradiography
  • Binding Sites
  • Brain Chemistry*
  • Caudate Nucleus / analysis
  • Cerebellum / analysis
  • Cerebral Cortex / analysis
  • Choroid Plexus / analysis
  • Freeze Drying
  • Hippocampus / analysis
  • Histocytochemistry
  • Injections, Intravenous
  • Lysergic Acid Diethylamide / administration & dosage
  • Lysergic Acid Diethylamide / analysis*
  • Lysergic Acid Diethylamide / metabolism
  • Mesencephalon / analysis
  • Olivary Nucleus / analysis
  • Pineal Gland / analysis
  • Pituitary Gland / analysis
  • Purkinje Cells / analysis
  • Rats
  • Superior Colliculi / analysis
  • Tegmentum Mesencephali / analysis
  • Time Factors
  • Tritium

Substances

  • Tritium
  • Lysergic Acid Diethylamide