A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474

Br J Cancer. 1971 Jun;25(2):270-5. doi: 10.1038/bjc.1971.33.


An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.The particular advantage of this drug is the low incidence of troublesome side effects.

MeSH terms

  • Adult
  • Aged
  • Alkenes / therapeutic use
  • Anabolic Agents / adverse effects
  • Anabolic Agents / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Chronic Disease
  • Diethylstilbestrol / adverse effects
  • Diethylstilbestrol / therapeutic use
  • Estrogen Antagonists*
  • Ethylamines / adverse effects
  • Ethylamines / therapeutic use*
  • Female
  • Humans
  • Middle Aged
  • Recurrence


  • Alkenes
  • Anabolic Agents
  • Estrogen Antagonists
  • Ethylamines
  • Diethylstilbestrol