Ganglioneuroma, heterochromia iridis, and Horner's syndrome

J Pediatr Surg. 1979 Oct;14(5):612-4. doi: 10.1016/s0022-3468(79)80152-9.


A child with mediastinal and supraclavicular ganglioneuroma, heterochromia iridis, and Horner's syndrome is described. The authors postulate that the thoracic neoplasm originated as a congenital neuroblastoma with metastasis to the supraclavicular lymph nodes and subsequent benign transformation, and that the ocular abnormalities resulted from sympathetic ganglion injury by the tumor in infancy. This seems to be the first published report of such ocular abnormalities associated with mediastinal ganglioneuroma.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Eye Color*
  • Female
  • Ganglioneuroma / complications*
  • Horner Syndrome / etiology*
  • Humans
  • Lymphatic Metastasis
  • Mediastinal Neoplasms / complications*
  • Mediastinal Neoplasms / pathology
  • Neuroblastoma / pathology