Porphyria and the dangerous life-threatening drugs

S Afr Med J. 1979 Nov 24;56(22):914-7.


The dangerous life-threatening drugs have been identified in 153 acute attacks in 138 porphyric patients by establishing a consistent temporal relationship between the administration of a specific drug and the development of an acute attack. The drugs so identified have been supplemented by a number of others found to be porphyrogenic by testing with a recently devised rat model. Lists of the dangerous and the safe drugs have been compiled.

MeSH terms

  • Barbiturates / adverse effects
  • Drug-Related Side Effects and Adverse Reactions
  • Female
  • Humans
  • Male
  • Physical Examination
  • Porphyrias / chemically induced*
  • Porphyrias / classification
  • Porphyrias / drug therapy


  • Barbiturates