Abstract
A double-blind cross-over trial with delta 9-tetrahydrocannabinol (THC) and placebo was employed to test the antiemetic effect on nausea and vomiting after MOPP-therapy. Although THC had remarkable antiemetic effects, the side effects were severe. Most patients preferred the nausea and the vomiting after MOPP-therapy to the use of THC. A relation between the antiemetic action or the side-effects and the blood-level of THC could not be demonstrated.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adult
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Antiemetics*
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Antineoplastic Agents / adverse effects*
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Double-Blind Method
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Dronabinol / adverse effects
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Dronabinol / blood
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Dronabinol / therapeutic use*
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Drug Therapy, Combination
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Female
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Hodgkin Disease / drug therapy*
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Humans
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Lymphoma / drug therapy*
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Male
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Mechlorethamine / adverse effects
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Middle Aged
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Placebos
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Prednisone / adverse effects
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Procarbazine / adverse effects
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Vincristine / adverse effects
Substances
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Antiemetics
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Antineoplastic Agents
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Placebos
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Procarbazine
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Mechlorethamine
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Vincristine
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Dronabinol
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Prednisone