Protective role of ceruloplasmin in inflammation

Agents Actions. 1979 Oct;9(4):333-6. doi: 10.1007/BF01970657.


Experimental inflammation in copper (Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy.

MeSH terms

  • Adult
  • Albumins / pharmacology
  • Animals
  • Arthritis, Rheumatoid / drug therapy
  • Ceruloplasmin / therapeutic use*
  • Copper / blood
  • Copper / deficiency
  • Female
  • Humans
  • Inflammation / drug therapy*
  • Male
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Rats
  • Uric Acid / pharmacology


  • Albumins
  • Uric Acid
  • Copper
  • Ceruloplasmin