Methotrexate and fertility in men

Arch Androl. 1979;3(2):177-9. doi: 10.3109/01485017908985067.


The possible deleterious effects of folic acid antagonist methotrexate on the fertility potential have been investigated in 26 male psoriatic patients. Examination for semen, testicular histology, and spermatogenic function using radioactive phosphorus revealed that methotrexate had no unfavorable effect on male fertility. A long follow up of the patients and their offspring is needed to exclude the possible teratogenic effect of the drug.

MeSH terms

  • Adult
  • Fertility* / drug effects
  • Humans
  • Male
  • Methotrexate / therapeutic use*
  • Middle Aged
  • Phosphates / metabolism
  • Psoriasis / drug therapy*
  • Psoriasis / pathology
  • Spermatogenesis / drug effects
  • Testis / metabolism
  • Testis / pathology


  • Phosphates
  • Methotrexate