Fine structural correlations between the muscle pathology of amyotrophic lateral sclerosis (ALS) patients and experimental Ca-Mg deficient rats

Experientia. 1979 Dec 15;35(12):1604-5. doi: 10.1007/BF01953218.


Nonspecific myofibrillar changes such as streaming of the Z-line, formation of rod-like structures, satellitosis, proliferation of sarcolemmal nuclei and papillary projection of the sarcolemma were recognized as a disorganization of the muscle itself. In addition, fine structural pathology in ALS specimens showed characteristically a pig-tail formation - 'Zopfformation' - which has been considered to have a neurogenic origin.

MeSH terms

  • Amyotrophic Lateral Sclerosis / pathology*
  • Animals
  • Calcium / deficiency*
  • Cell Nucleus / ultrastructure
  • Disease Models, Animal
  • Humans
  • Magnesium Deficiency*
  • Muscles / pathology*
  • Muscles / ultrastructure
  • Rats
  • Sarcolemma / ultrastructure


  • Calcium