Spontaneous endocrine tumors in Sprague-Dawley rats

J Cancer Res Clin Oncol. 1979 Oct;95(2):187-96. doi: 10.1007/BF00401012.


Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

MeSH terms

  • Adrenal Gland Neoplasms / veterinary
  • Animals
  • Endocrine Glands*
  • Female
  • Male
  • Neoplasms / epidemiology
  • Neoplasms / veterinary*
  • Neoplasms, Multiple Primary / veterinary
  • Pancreatic Neoplasms / veterinary
  • Pheochromocytoma / veterinary
  • Pituitary Neoplasms / veterinary
  • Rats
  • Rodent Diseases / epidemiology*
  • Thyroid Neoplasms / veterinary