A treatment of cancer by the application of external electromagnetic energy at a resonant frequency capable of the generation of heat intracellularly to induce selective thermal death of cancer cells is described. This process also allows for the detection of cancer cells by the use of differential resonant frequencies including nuclear magnetic resonance and electron spin resonance techniques. This process permits the selective treatment of cancer cells by the compartmentalized alteration of biophysical properties in the cancer cells and the detection of cancer cells by determination of their biophysical properties. The process comprises an ability to determine the respective resonant frequencies of cancer cells and normal cells at a cellular level. An external alternating electromagnetic field is then applied at the resonant frequency of the cancer cells which differs from the resonant frequency of the normal cells. The cancer cells absorb significant energy at this resonant frequency whereas the normal cells absorb minimal energy at this frequency. Generating the heat intracellularly instead of extracellularly results in the cell's membrane, which is an effective thermal barrier, enhancing the process by keeping the heat within the cell instead of outside of the cell. This process is enhanced by the nuclear differences between cancer cells and normal cells and by the energy changes characteristic of structural and conformational changes in the deoxyribonucleic acid and the histones of the nucleus including their interrelationship. This process promises great efficacy in the diagnosis and the treatment of neoplastic and also perhaps of artherosclerotic diseases.