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, 66 (1), 153-9

Dolichol Monophosphate Glucose: An Intermediate in Glucose Transfer in Liver

Dolichol Monophosphate Glucose: An Intermediate in Glucose Transfer in Liver

N H Behrens et al. Proc Natl Acad Sci U S A.

Abstract

The microsomal fraction of liver has been found to catalyze glucose transfer from UDPG to a lipid acceptor which appears to be identical to the compound obtained by chemical phosphorylation of dolichol. The substance formed (dolichol monophosphate glucose) is acid labile and yields 1,6-anhydroglucosan by alkaline treatment. It can be used as substrate by the enzyme system yielding a glucoprotein which is subsequently hydrolyzed to glucose.

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