Dolichol monophosphate glucose: an intermediate in glucose transfer in liver

Proc Natl Acad Sci U S A. 1970 May;66(1):153-9. doi: 10.1073/pnas.66.1.153.

Abstract

The microsomal fraction of liver has been found to catalyze glucose transfer from UDPG to a lipid acceptor which appears to be identical to the compound obtained by chemical phosphorylation of dolichol. The substance formed (dolichol monophosphate glucose) is acid labile and yields 1,6-anhydroglucosan by alkaline treatment. It can be used as substrate by the enzyme system yielding a glucoprotein which is subsequently hydrolyzed to glucose.

MeSH terms

  • Alcohols / metabolism*
  • Animals
  • Carbon Isotopes
  • Chromatography, Thin Layer
  • Glucose / metabolism*
  • Glycoproteins / metabolism
  • Hexosephosphates / metabolism*
  • In Vitro Techniques
  • Lipid Metabolism
  • Liver / metabolism*
  • Microsomes, Liver / metabolism
  • Swine
  • Uracil Nucleotides / metabolism

Substances

  • Alcohols
  • Carbon Isotopes
  • Glycoproteins
  • Hexosephosphates
  • Uracil Nucleotides
  • Glucose