Chronic pancreatitis and alpha-1-antitrypsin

Lancet. 1975 Oct 18;2(7938):748-9. doi: 10.1016/s0140-6736(75)90728-x.


110 patients with proven chronic pancreatitis have been studied to assess the prevalence of the various Pi phenotypes of alpha1-antitrypsin in this disease compared with a control group of 116 blood-donors. The phenotype PiMZ (including Mweak) was significantly more prevalent and PiMM significantly less so in the patients with pancreatitis. It is possible that a heterozygous deficiency of this protease inhibitor renders the pancreas more vulnerable to aetiological agents (e.g., alcohol).

MeSH terms

  • Blood Donors
  • Chronic Disease
  • Homozygote
  • Humans
  • Pancreatitis / enzymology*
  • Pancreatitis / etiology
  • Pancreatitis / genetics
  • Phenotype
  • alpha 1-Antitrypsin / blood
  • alpha 1-Antitrypsin Deficiency*


  • alpha 1-Antitrypsin