Abstract
Antibodies to ribonucleoprotein are the serological marker of mixed connective tissue disease (MCTD). Five patients are presented who had negative or low titer anti-RNP antibodies despite characteristic MCTD. In all 5 patients antibodies to RNP appeared after they had taken prednisone for periods ranging from 3 wk to 15 months.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Antibodies / analysis*
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Female
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Humans
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Middle Aged
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Mixed Connective Tissue Disease / blood
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Mixed Connective Tissue Disease / drug therapy
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Mixed Connective Tissue Disease / immunology*
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Ribonucleoproteins / immunology
Substances
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Adrenal Cortex Hormones
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Antibodies
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Ribonucleoproteins