Mixed connective tissue disease. Appearance of antibodies to ribonucleoprotein following corticosteroid treatment

J Rheumatol. 1979 Nov-Dec;6(6):694-9.

Abstract

Antibodies to ribonucleoprotein are the serological marker of mixed connective tissue disease (MCTD). Five patients are presented who had negative or low titer anti-RNP antibodies despite characteristic MCTD. In all 5 patients antibodies to RNP appeared after they had taken prednisone for periods ranging from 3 wk to 15 months.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Antibodies / analysis*
  • Female
  • Humans
  • Middle Aged
  • Mixed Connective Tissue Disease / blood
  • Mixed Connective Tissue Disease / drug therapy
  • Mixed Connective Tissue Disease / immunology*
  • Ribonucleoproteins / immunology

Substances

  • Adrenal Cortex Hormones
  • Antibodies
  • Ribonucleoproteins