Antibody to hepatitis B core antigen

Am J Med Sci. 1975 Jul-Aug;270(1):179-87. doi: 10.1097/00000441-197507000-00025.


Two distinct antigen-antibody systems are associated with the hepatitis B virus (HBV): hepatitis B surface antigen (HBs Ag) and antibody (anti-HBs) and the more recently described hepatitis B core antigen (HBc Ag) and antibody (anti-HBc). Testing of serial serum samples from patients with type B hepatitis demonstrates the regular occurrence of anti-HBc during the course of this disease. In general, highest titers of anti-HBc are seen with prolonged circulation of HBs Ag as in the chronic carrier state. Titers of anti-HBc begin to fall with recovery from HBV infection and anti-HBc appears to be shorter lived than anti-HBs. As such, anti-HBc testing is important in documenting the occurrence of infection with HBV and is of great value in epidemiologic studies and in evaluating the safety and efficacy of hepatitis B immune globulin and HBV vaccines.

MeSH terms

  • Animals
  • Antibodies, Viral / classification
  • Antibodies, Viral / isolation & purification*
  • Antibody Formation
  • Antibody Specificity
  • Antigen-Antibody Reactions
  • Carrier State
  • Cell Membrane / immunology
  • Epitopes
  • Hepatitis B / immunology*
  • Hepatitis B Antigens / classification
  • Hepatitis B Antigens / isolation & purification*
  • Hepatitis B virus / analysis*
  • Humans
  • Immunization
  • Immunoglobulins / isolation & purification
  • Pan troglodytes


  • Antibodies, Viral
  • Epitopes
  • Hepatitis B Antigens
  • Immunoglobulins