Abstract
The isolation and purification of split-products from tetanus toxin after freezing is reported. Antigenically defective and non-defective fragments exhibiting reduced molecular weights with respect to that of intact toxin were investigated as to their biological and immunological properties. The results obtained are discussed in relation to other data from the literature.
MeSH terms
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Animals
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Antibody Formation
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Antigen-Antibody Reactions
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Antigens, Bacterial / analysis*
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Chromatography, Gel
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Drug Storage
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Electrophoresis, Polyacrylamide Gel
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Epitopes*
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Flocculation Tests
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Freezing
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Immune Sera / isolation & purification
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Immunodiffusion
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Lethal Dose 50
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Mice
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Molecular Weight
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Precipitin Tests
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Rabbits
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Tetanus Toxin* / analysis
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Tetanus Toxin* / isolation & purification
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Tetanus Toxin* / toxicity
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Toxoids / isolation & purification
Substances
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Antigens, Bacterial
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Epitopes
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Immune Sera
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Tetanus Toxin
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Toxoids