Stimulating effect of angiotensin II on the spontaneous release of newly synthetized [3H]dopamine in rat striatal slices

Neurosci Lett. 1979 Dec;15(2-3):153-8. doi: 10.1016/0304-3940(79)96105-6.

Abstract

Angiotensin II (A II) (10(-6) M, 10(-5) M, 5 . 10(-5) M) stimulated the spontaneous release of [3H]dopamine (DA) continuously synthetized from [3H]tyrosine in striatal slices of the rat. The A II-evoked release of [3H]-DA was prevented when slices were superfused with a calcium-free medium containing EGTA 5 . 10(-4) M. It was also suppressed in the presence of the potent antagonist Sar1-Ile8-angiotensin.

MeSH terms

  • Angiotensin II / pharmacology*
  • Animals
  • Corpus Striatum / analysis
  • Corpus Striatum / drug effects*
  • Corpus Striatum / metabolism
  • Dopamine / metabolism*
  • Hypothalamus / metabolism
  • In Vitro Techniques
  • Male
  • Norepinephrine / metabolism
  • Rats
  • Receptors, Angiotensin / analysis
  • Receptors, Angiotensin / drug effects
  • Stimulation, Chemical

Substances

  • Receptors, Angiotensin
  • Angiotensin II
  • Dopamine
  • Norepinephrine