Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration

Pharmacol Biochem Behav. 1979 Nov;11(5):553-6. doi: 10.1016/0091-3057(79)90040-6.


Control rats initiate self-administration of d-amphetamine and achieve stable injection rates within 7-10 days. Rats in which dopamine nerve terminals in nucleus accumbens were destroyed by bilateral microinjections of 6-hydroxydopamine (6-OHDA) did not initiate self-administration of d-amphetamine when tested for as long as 19 days. In rats previously trained to self-administer d-amphetamine, 6-OHDA injections into nucleus accumbens abolished d-amphetamine self-administration. These results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Conditioning, Operant / drug effects
  • Dextroamphetamine / administration & dosage*
  • Dopamine / physiology*
  • Hydroxydopamines / pharmacology
  • Male
  • Nerve Endings / physiology*
  • Nucleus Accumbens / physiology*
  • Rats
  • Self Administration / psychology
  • Septal Nuclei / physiology*


  • Hydroxydopamines
  • Dextroamphetamine
  • Dopamine