A theoretical study of quantitative flow measurements with constant infusion of short-lived isotopes

Phys Med Biol. 1979 Nov;24(6):1151-61. doi: 10.1088/0031-9155/24/6/005.


Recent developments in the technique of constant infusion and in emission computed tomography have provided a new method for quantitative regional flow measurements. This paper re-examines critically the theoretical relationship between flow and radioactivity during constant infusion of short-lived isotopes. Sensitivity analysis is used to assess the accuracy of the method. Criteria for the selection of an appropriate half-life to meet accuracy requirements are also discussed. A method for the determination of the distribution volume of the tracer is proposed.

MeSH terms

  • Blood Circulation*
  • Mathematics
  • Radioisotopes* / administration & dosage
  • Regional Blood Flow


  • Radioisotopes