Abstract
PGH3 was biosynthesised from all-cis-5,8,11,14,17-eicosapentaenoic acid (20:5 omega 3) by an acetone-pentane powder of ram seminal vesicles and its structure was confirmed by GLC-MS after its reduction to PGF 3 alpha. PGH3 was transformed by horse platelet microsomes to TXB3, and by aortic microsomes to delta 17-6-keto-PGF 1 alpha. The structures of these compounds were confirmed by GLC-MS.
MeSH terms
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Animals
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Aorta / metabolism
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Blood Platelets / metabolism
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Eicosanoic Acids
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Fatty Acids, Unsaturated
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Gas Chromatography-Mass Spectrometry
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Horses
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Male
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Microsomes / metabolism
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Prostaglandin Endoperoxides / biosynthesis*
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Prostaglandins F / metabolism
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Prostaglandins H / biosynthesis*
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Prostaglandins H / metabolism
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Seminal Vesicles / cytology
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Seminal Vesicles / metabolism
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Sheep
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Thromboxanes / metabolism
Substances
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Eicosanoic Acids
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Fatty Acids, Unsaturated
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Prostaglandin Endoperoxides
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Prostaglandins F
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Prostaglandins H
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Thromboxanes