Preparation and biochemical properties of PGH3

Prostaglandins. 1979 Sep;18(3):423-38. doi: 10.1016/s0090-6980(79)80061-1.

Abstract

PGH3 was biosynthesised from all-cis-5,8,11,14,17-eicosapentaenoic acid (20:5 omega 3) by an acetone-pentane powder of ram seminal vesicles and its structure was confirmed by GLC-MS after its reduction to PGF 3 alpha. PGH3 was transformed by horse platelet microsomes to TXB3, and by aortic microsomes to delta 17-6-keto-PGF 1 alpha. The structures of these compounds were confirmed by GLC-MS.

MeSH terms

  • Animals
  • Aorta / metabolism
  • Blood Platelets / metabolism
  • Eicosanoic Acids
  • Fatty Acids, Unsaturated
  • Gas Chromatography-Mass Spectrometry
  • Horses
  • Male
  • Microsomes / metabolism
  • Prostaglandin Endoperoxides / biosynthesis*
  • Prostaglandins F / metabolism
  • Prostaglandins H / biosynthesis*
  • Prostaglandins H / metabolism
  • Seminal Vesicles / cytology
  • Seminal Vesicles / metabolism
  • Sheep
  • Thromboxanes / metabolism

Substances

  • Eicosanoic Acids
  • Fatty Acids, Unsaturated
  • Prostaglandin Endoperoxides
  • Prostaglandins F
  • Prostaglandins H
  • Thromboxanes