Treatment of Radiation-Induced Gastrointestinal Distress With Acetylsalicylate

Lancet. 1975 Nov 15;2(7942):942-3. doi: 10.1016/s0140-6736(75)90358-x.

Abstract

Highly buffered acetylsalicylate was used to treat diarrhoea and other gastrointestinal side-effects of radiotherapy in 28 women who were receiving treatment for uterine cancer. In a double-blind, balanced, and randomised trial, acetylsalicylate significantly reduced the number of bowel motions and relieved abdominal pain and flatulence.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antacids / administration & dosage
  • Antacids / therapeutic use
  • Aspirin / administration & dosage
  • Aspirin / therapeutic use*
  • Buffers
  • Clinical Trials as Topic
  • Diarrhea / drug therapy*
  • Diarrhea / etiology
  • Drug Combinations
  • Drug Evaluation
  • Female
  • Humans
  • Nausea / drug therapy*
  • Nausea / etiology
  • Radiation Injuries / drug therapy*
  • Radiotherapy / adverse effects*
  • Uterine Cervical Neoplasms / radiotherapy

Substances

  • Antacids
  • Buffers
  • Drug Combinations
  • Aspirin