Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 37 (1), 69-78

Studies on the Peripheral Pharmacology of Fenazoxine, a Potential Antidepressant Drug

Studies on the Peripheral Pharmacology of Fenazoxine, a Potential Antidepressant Drug

J R Bassett et al. Br J Pharmacol.


1. The action of fenazoxine, a cyclized analogue of orphenadrine, has been studied on peripheral tissues innervated by adrenergic and cholinergic nerves. The hypothesis that cyclization of the alkyl amino chain of orphenadrine results in a molecule which retains the noradrenaline sensitizing action of orphenadrine but lacks the antimuscarinic activity has been investigated.2. The antimuscarinic activity of fenazoxine, on guinea pig ileum, was approximately 1/30 that of orphenadrine.3. Fenazoxine, desmethylimipramine and cocaine potentiated the response to noradrenaline and sympathetic nerve stimulation on the cat nictitating membrane, isolated rabbit ear artery and isolated driven atrial strip preparations.4. On the driven atrial strip preparation, fenazoxine at concentrations of 5 x 10(-7)M and 1 x 10(-6)M produced a small potentiation of the inotropic response to isoprenaline. At 5 x 10(-6)M and 5 x 10(-5)M fenazoxine antagonized the inotropic response to tyramine.5. Chronic denervation of the cat nictitating membrane abolished the potentiating action of fenazoxine.6. The results presented suggest that fenazoxine inhibits the uptake of catecholamines in a manner similar to that reported for desmethylimipramine and cocaine.7. Evidence is also presented which suggests that fenazoxine, like desmethylimipramine, possesses anti-noradrenaline activity at higher concentrations.

Similar articles

See all similar articles

Cited by 9 PubMed Central articles

See all "Cited by" articles


    1. Eur J Pharmacol. 1968 Sep;4(2):198-204 - PubMed
    1. J Pharmacol Exp Ther. 1966 Feb;151(2):221-35 - PubMed
    1. Br J Pharmacol Chemother. 1964 Feb;22:5-21 - PubMed
    1. Eur J Pharmacol. 1969 Feb;5(3):296-8 - PubMed
    1. Acta Pharmacol Toxicol (Copenh). 1966;24(4):297-309 - PubMed

MeSH terms