Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets

Br J Pharmacol. 1969 Nov;37(3):680-8. doi: 10.1111/j.1476-5381.1969.tb08506.x.


1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.

MeSH terms

  • Animals
  • Biological Transport, Active*
  • Blood Platelets / metabolism*
  • Cell Membrane / metabolism
  • In Vitro Techniques
  • Kinetics
  • Male
  • Potassium / analysis
  • Potassium / pharmacology
  • Rats
  • Serotonin / metabolism*
  • Sodium / analysis
  • Sodium / pharmacology*
  • Tritium


  • Tritium
  • Serotonin
  • Sodium
  • Potassium