A prospective study of cow's milk protein intolerance in Swedish infants

Acta Paediatr Scand. 1979 Nov;68(6):853-9. doi: 10.1111/j.1651-2227.1979.tb08223.x.


1 079 of 1 548 newborn infants were followed during their first year. 328 were prospectively contacted once a month. 751 were followed up at child welfare clinics. Altogether 20 were diagnosed as being cow's milk protein intolerant (1.9%). Symptoms from the gastrointestinal tract and the skin predominated. Only 2 had respiratory symptoms. Ten had their symptoms within one week after the introduction of cow's milk, 3 of them at their first cow's milk-containing meal. A further 4 already had symptoms when fed only human milk. The others (6 infants) showed symptoms after more than one week on a cow's milk containing diet. Before 2 years of age, 13 had recovered. Twelve of the cow's milk protein intolerant infants also showed adverse reactions to other foods, soy-protein intolerance being the most common (7 infants). A family history of allergy was found in 35% (116) of the 328 infants and in 70% (14) of those with cow's milk protein intolerance.

MeSH terms

  • Age Factors
  • Animals
  • Cattle
  • Female
  • Follow-Up Studies
  • Food Hypersensitivity / diagnosis
  • Food Hypersensitivity / epidemiology*
  • Food Hypersensitivity / genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Milk / adverse effects*
  • Milk Proteins / adverse effects*
  • Prospective Studies
  • Sweden
  • Time Factors


  • Milk Proteins