Changes observed in bone during hibernation using Procion red dye as a matrical marker

J Exp Zool. 1979 Dec;210(3):537-41. doi: 10.1002/jez.1402100317.


Visual examination of the intensity of Procion dye in hamster femurs revealed that dye incorporation decreased during hibernation. Little or no dye was observed after hibernation lasting longer than 50 days. It seems that hibernation may be associated with increased bone resorption and a loss of bone matrix.

MeSH terms

  • Animals
  • Bone Matrix / metabolism*
  • Bone Resorption*
  • Coloring Agents*
  • Cricetinae
  • Female
  • Femur
  • Hibernation*
  • Male
  • Mesocricetus
  • Time Factors
  • Triazines*


  • Coloring Agents
  • Triazines
  • Procion Brilliant Red M-2BS