Photochromogenic and scotochromogenic mycobacteria: their clinical significance

Acta Microbiol Acad Sci Hung. 1979;26(3):185-92.

Abstract

In the period 1973--1977, Mycobacterium tuberculosis was isolated by cultivation in 4408 cases from the clinical specimens of patients with positive X-ray findings. On the basis of atypical colony morphology or pigment formation, 263 other mycobacterial strains were identified: of these 23 were photochromogenic and belonged to Mycobacterium kansasii. The strains were cultured on several occasions from the specimens of 4 patients with broncho-pulmonary mycobacteriosis. The strains were resistant to isoniazid and streptomycin, sensitive to ethambutol and rifampicin. A total of 18 scotochromogenic isolates cultured from 14 patients with positive X-ray findings were identified as Mycobacterium aquae (M. gordonae) and its variants: strains showing slow Tween hydrolysis and 1 strain of rapid growth. In 5 cases M. tuberculosis was also obtained, indicating the presence of a mixed mycobacterial population. All scotochromogens were resistant to isoniazid and sensitive to ethambutol, with the exception of two strains sensitive to rifampicin.

MeSH terms

  • Humans
  • Immunoglobulins / analysis
  • Leukocyte Count
  • Lymphocytes
  • Mycobacterium / isolation & purification*
  • Mycobacterium Infections, Nontuberculous / immunology
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Nontuberculous Mycobacteria / isolation & purification*
  • Nontuberculous Mycobacteria / physiology
  • Pigments, Biological / biosynthesis
  • Tuberculosis, Pulmonary / immunology
  • Tuberculosis, Pulmonary / microbiology*

Substances

  • Immunoglobulins
  • Pigments, Biological