Immunotherapy of an ascitic rat hepatoma with cord factor (trehalose-6, 6'-dimycolate) and synthetic analogues

Int J Cancer. 1979 Dec 15;24(6):780-5. doi: 10.1002/ijc.2910240614.

Abstract

The ability of cord factor (trehalose-6, 6'-dimycolate) and a range of shorter carbon chain fatty acid trehalose diesters to suppress growth of an ascitic rat hepatoma has been examined and compared with that of whole, living BCG organisms. Aqueous suspensions of BCG, and cord factor in 0.4% arachis oil:Triton emulsion, injected intraperitoneally, retarded growth of up to 10(5) ascites tumour cells. Trehalose-6, 6'-dibehenate was also tumour-suppressive, but only against lower challenge inocula (10(4) cells). Trehalose-6, 6'-dipalmitate and 6,6'-di-0-2-tetradecyl -3-hydroxyoctadecanoyl alpha, alpha trehalose (designated C76) were virtually ineffective and 6,6' -di-0-2-eicosyl-3-hydroxy-tetracosanoyl alpha, alpha trehalose (designated C100) gave small and variable effects only against low challenge inocula. However, improved responses were seen with light mineral oil in place of arachis oil in the emulsions.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • BCG Vaccine / therapeutic use
  • Cord Factors / administration & dosage
  • Cord Factors / therapeutic use*
  • Emulsions
  • Glycolipids / therapeutic use*
  • Immunotherapy
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Liver Neoplasms, Experimental / therapy*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Trehalose / analogs & derivatives

Substances

  • BCG Vaccine
  • Cord Factors
  • Emulsions
  • Glycolipids
  • Trehalose