Free and protein-bound glutathione in normal and cataractous human lenses

Biochem J. 1970 May;117(5):957-60. doi: 10.1042/bj1170957.


Protein-bound glutathione was identified and measured in normal and cataractous human lenses. In a major group of cataracto us lenses the bound glutathione concentration was higher than normal. Study of normal lenses showed that their glutathione content is age-dependent, decreasing steadily from about 3.5mumol/g of lens at age 20 years to about 1.8mumol/g of lens at age 65 years. Cataract brings further decreases.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Cataract / metabolism*
  • Child
  • Electrophoresis
  • Glutathione / analysis*
  • Humans
  • Lens, Crystalline / analysis*
  • Middle Aged
  • Protein Binding*


  • Glutathione